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KMID : 0644320000060010019
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Journal of Korean Oriental Oncology
2000 Volume.6 No. 1 p.19 ~ p.28
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Study on toxicity, anti-cancer and NK cell activity of Laetril oil.
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심범상/Shim, Bum-Sang
최승훈/박재경/Choi, Seung-hoon/Park, Jai-Kyung
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Abstract
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In this experiment, we examined the the effect of Laetrile Oil to the immune system and tried to disclose the anti-cancer mechanism of this. The result is listed as below.
1. After per-os, sub-cutaneous and into the peritonal injection of Laetrile Oil to the SPF mice, the LD50 is above 5ooomg/kg at even roup.
2. Mean survival days of mice treated with laetril oil, after S-180 cells transplantation into the eritoneal cavoty decreases 1.5 days(-6.8%) compared with the Mean survival days of the control group(22days.)
3. Effects of laetril oil on natural killer cell activity at Effector/Target Cell Ratio with 100:1, 50:1, l0:l into methotrexate-pretreated mice is like this.: Compared with 29.22±l2.7% Cytotoxicity of the control group, sample group´s Cytotoxicity had 38.83±l2.5% of meaningful acrease. At l00:1 Effecr/Target Cell Ratio. At 50:l Effector/Target Cell Ratio, control group has 20.02±9.6%
Cytotoxiciy and sample group had 3l.53±13.4% Cytotoxicity. At 25:l Effector/Target Cell Ratio, control group has 13.60±6.6% Cytotoxicity and sample group had 20.8l±9.8% Cytotoxicity. According to the above results, the Laetrile Oil represents nontotoxic to a SPF mice. non-effective to transplantable Sarcoma 180 tumors, and activaion in NK cell activity.
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